Quality Standard：【产品介绍】B-Raf, also know as c-Rmil, is
a Serine/Threonine protein kinase member of the Raf
family which includes Raf-1 a n d A-Raf. B-Raf is
involved in the transduction of mitogenic signals from
the cell membrane to the nucleus (1). Composed of
three conserved region (CR1, CR2, CR3) B-Raf is
expressed primarily in the brain a n d in the nervous
system (2). It has been observed that MAPK is activated
by B-Raf in response to nerve growth fact o r (3).
M o r e than 60% of malignant melanomas were found
to contain a specific mutation, B-Raf (V599E) the product
of which possesses constitutive kinase activity
(4). Mutations in B-Raf have also been identified in
lung cancer a n d non-Hodgkin lymphoma.
WB: 1:1000 - 5000
ICC: 1:100 – 250
IP: 1:20
A. Western blot analysis on PC-12 cell lysates
using anti-Phospho-B-Raf (p401) RabMAb
(cat. #2298-1), 1:5000 dilution. Cells were
either (A) untreated (B) treated with TPA.
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