Quality Standard:【产品介绍】Erzin, a member of the Ezrin, Radixin,
Moesin (ERM) family, is a linker protein located
between cell surface recept o r s, adhesion molecules,
a n d actin cytoskeleton (1-2). Ezrin activity is
regulated by intramolecular interactions between
N- a n d C-terminal ERM association domains (3). Phosph
o r ylation at threonine 567 is a critical regulat o r
of Ezrin function allowing the active protein to link
target molecules to the actin cytoskeleton (4).
Erzin tyrosine phosph o r ylation can also be induced
by EGF, PDGF a n d HGF stimulation. Erzin interacts
with PI3-K protein kinase A a n d Rho (5).
WB: 1:200,000
ICC: 1:100 - 250
A. Western blot analysis on 293 cell lysates
using anti-Phospho-Ezrin (pY353) RabMAb
(cat. #1894-1), 1:200,000 dilution. Cells were
either (A) untreated (B) treated with pervanadate.