Quality Standard：【产品介绍】Junctional Adhesion Molecules (JAMs)
are components a n d regulat o r s of the well-
characterized epithelial a n d endothelial tight
junction. JAM is s e l e c tively concentrated
at intercellular junctions of endothelial a n d
epithelial cells of different o r igins. Microscopy
shows that JAM codistributes with tight junction
components at the apical region of the intercellular
cleft. A mAb directed to JAM (BV11) was found to
inhibit spontaneous a n d chemokine-induced
monocyte transmigration through an endothelial
cell monolayer in vitro. Systemic treatment of mice
with BV11 mAb blocked monocyte infiltration upon
chemokine administration in subcutaneous air pouches
(1). The human protein shares a highly conserved structure
a n d sequence with the murine protein. However it
is distinct in that it is constitutively expressed
on circulating neutrophils, monocytes, platelets
a n d lymphocyte subsets (2).
WB: 1:2000
IHC: 1:100 - 250
A. Western blot analysis on HeLa cell lysate using
anti-JAM1 RabMAb (cat. #1840-1), dilution 1:2000
B. Immunohistochemical staining of paraffin-embedded
human liver using anti-JAM1 RabMAb (cat. #1840-1).
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