Quality Standard：【产品介绍】Estrogen-related receptor alpha (ERR alpha)
is an orphan member of the superfamily of nuclear
hormone receptors. ERR alpha was initially isolated based
on its sequence homology to the estrogen receptor but is
not activated by classic estrogens. Binding site
selection experiments show that ERR alpha
preferentially binds to an ERR alpha response element
(ERRE) containing a single consensus half-site,
TNAAGGTCA. Data demonstrate that ERR alpha can control
the expression of MCAD through the NRRE-1 and thus may
play an important role in regulating cellular energy
balance in vivo (1). The estrogen-related receptors
ERRalpha and ERRbeta (formerly ERR1 and ERR2) form
a subgroup of the steroid/thyroid/retinoid receptor
family. ERRalpha and ERRbeta are homologous to the
estrogen receptor and bind similar DNA targets;
however, they are unable to activate gene transcription
in response to estrogens (2).
Recommended Applications
WB, IP, FC
Applications and Recommended Dilution Factors
WB: 1:2500 5000
IP: 1:40
FC: 1:20
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity determined by western blot only.
Products Data
A. Western blot analysis on HeLa cell lysate using
anti-ERR alpha RabMAb (cat. # 2131-1), dilution 1:5000.
Specificity
A synthetic peptide corresponding to residues near
the N-terminus of human ERRalpha was used as an immunogen.
Storage：Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.
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