HLA-Drb1

Molecular Formula：

Molecular Weight：

Alias：
HLA-DRB1 antibody, DRB1 antibody, DRw10 antibody, FLJ75017 antibody, FLJ76359 antibody, HLA-DR1B antibody, HLA-DRB antibody, HLA-DRB1* antibody, SS1 antibody, HLA class II histocompatibility antigen, DRB1-1 beta chain antibody, MHC class II antigen DRB1*1

Product order：

Name	Specifications	Packing	Price	Delivery
HLA-Drb1		100ul	Inquiry	现货

Character：
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPR6148
【用途】WB , IHC , ICC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】30kDa

Quality Standard：
【产品介绍】HLA-Drb1 belongs to the HLA class II beta
chain paralogs. The class II molecule is a
heterodimer consisting of an alpha (DRA) and a beta
chain (DRB), both anchored in the membrane. It plays
a central role in the immune system by presenting
peptides derived from extracellular proteins. Class
II molecules are expressed in antigen presenting cells
(APC: B lymphocytes, dendritic cells, macrophages). The
beta chain is approximately 26-28 kDa. Within the
DR molecule the beta chain contains all the
polymorphisms specifying the peptide binding
specificities. Hundreds of HLA-Drb1 variations have
been described, and typing for these polymorphisms
is routinely done for bone marrow and
kidney transplantation. HLA-Drb1 is expressed at a
level five times higher than its paralogs DRB3, DRB4
and DRB5. HLA-Drb1 is present in all individuals.
Variants of HLA-Drb1 are linked with either none or one
of the proteins for DRB3, DRB4 and DRB5 (1).

Recommended Applications
WB, IHC, ICC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) human spleen, (B) lymph
node, (C) Ramos, and (D) human tonsil lysates
using anti-HLA-Drb1 RabMAb (cat. #5352-1).

Immunohistochemical analysis of paraffin-embedded
human tonsil tissue using anti-HLA-Drb1 RabMAb
(cat. #5352-1).

Specificity
A synthetic peptide corresponding to residues in
human HLA-Drb1 was used as an immunogen.

Storage：
Store at -20 °C. Antibody buffer, 0.01% sodium azide,
50% Glycerol and 0.05% BSA. Stable for 12 months from date
of receipt