质量标准：【产品介绍】CrkL (Crk-like), a 36kDa protein
predominantly expressed in hematopoietic cell lines, is
a member of the Crk adapter protein family. Lacking
any intrinsic enzymatic activity, CrkL is composed of
one SH2 domain a n d two SH3 domains (1). The SH2 domain
of CrkL as been shown to interact with c-Cbl, Cas, Hef-1
a n d Paxillin (2); while the N-terminal SH3 can bind
to c-ABL, Sos1 a n d C3G (3). Additionally, the phosph
o r ylated f o r m of CrkL (pY207) binds to BCR-ABL
oncogene in chronic myelogenous leukemia cells (4).
WB: 1:1,000
IHC: 1:50-100
ICC: 1:50-100
A. Western blot analysis on K562 cell lysate using
anti-CrkL RabMAb (cat. # 1537-1), dilution 1:1,000.
B. Immunohistochemical analysis of paraffin-embedded
human breast carcinoma using anti-CrkL RabMAb
(cat. # 1537-1).
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