Quality Standard：【产品介绍】Factor XIII (plasma transglutaminase,
fibrin stabilizing factor) is a plasma protein that plays
an important role in the final stages of blood
coagulation and fibrinolysis. It circulates in blood as
a tetramer consisting of two “A” and two “B”
subunits (1, 2). The amino acid sequence of
the enzymatically active subunit, Factor XIII A, is
unique and does not exhibit internal homology, but
its active center is similar to that of the thiol
proteases. Factor XIII A is activated by thrombin
and calcium ion to a transglutaminase that catalyzes
the cross linking of fibrin molecules,
forming intermolecular isopeptide bonds, thus
stabilizing blood clots (3, 4). In two diseases that
share some histological resemblance (Lymphocyte-poor
graft-versus-host-reaction and toxic epidermal
necrolysis), Factor-XIII A-positive dendrocytes show
some morphological changes, probably as a response
to altered cytokine environment. Factor-XIII
A-positive dendrocytes thus are reported to possibly play
a role in the regulation of the connective
tissue remodeling that may accompany epidermal
destruction (5).
Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:1000 - 2000
IP: 1:20
Species Reactivity *
Human, Rat
*Cross reactivity determined by western blot only.
Products Data
A. Western blot analysis on (A) human placenta, (B) PBMC
and (C) rat platelet lysates using anti-Factor XIII A
RabMAb (cat. #2597-1).
Specificity
A synthetic peptide corresponding to residues in
human Factor XIII A was used as an immunogen.
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