IDO (IDO1)

Molecular Formula：

Molecular Weight：

Alias：
IDO1 antibody, IDO antibody, IDO-1 antibody, INDO antibody, Indoleamine 2,3-dioxygenase 1 antibody, Indoleamine-pyrrole 2,3-dioxygenase antibody

Product order：

Name	Specifications	Packing	Price	Delivery
IDO (IDO1)		100ul	Inquiry	现货

Character：
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPR1229(2)
【用途】WB
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】42kDa

Quality Standard：
【产品介绍】T lymphocytes undergo proliferation arrest
when exposed to tryptophan shortage, which can be
provoked by indoleamine 2,3-dioxygenase (IDO), an
enzyme that is expressed in placenta and
catalyzes tryptophan degradation. Most human
tumors constitutively express IDO. Results suggest that
the efficacy of therapeutic vaccination of cancer
patients might be improved by concomitant administration
of an IDO inhibitor (1). Certain macrophages, induced
to express IDO in response to interferon-gamma and
other signals from activating T cells, inhibit
T-cell proliferation in vitro by rapidly
consuming tryptophan. Because IDO is also expressed by
human syncytiotrophoblast cells and systemic
tryptophan concentration falls during normal pregnancy,
it is believed that IDO expression at the maternal-
fetal interface is necessary to prevent
immunologic rejection of the fetal allografts (2).

Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
Species Reactivity *
Human
*Species cross-reactivity is based on WB analysis.
Products Data

Western blot analysis on HeLa treated with IFN-gamma
cell lysate using anti-IDO RabMAb (cat. #5133-1).

Specificity
A synthetic peptide corresponding to residues in human
IDO was used as an immunogen.

Storage：
Store at -20 °C. Antibody buffer, 0.01% sodium azide,
50% Glycerol and 0.05% BSA. Stable for 12 months from date
of receipt