KDR / VEGFR-2

Molecular Formula：

Molecular Weight：

Alias：
KDR antibody, CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, Vascular endothelial growth factor receptor 2 antibody, Kinase insert domain receptor antibody, Protein-tyrosine kinase receptor flk-1 antibody

Product order：

Name	Specifications	Packing	Price	Delivery
KDR / VEGFR-2		100ul	Inquiry	现货

Character：
【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPRER16Y
【用途】WB , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】210/230 KDa

Quality Standard：
【产品介绍】The expression of VEGF and KDR correlates
highly with the normal ocular vascularization in humans,
but VEGF may also be necessary for nonvascular
retinal developmental functions, especially for
the coordination of neural retinal development and
the preliminary steps of the establishment of the
definitive stable retinal vasculature (1). KDR/flk-1 is
one of two receptors for vascular endothelial growth
factor, a potent angiogenic peptide. KDR/flk-1 is an
early marker for endothelial cell progenitors, and
its expression is restricted to endothelial cells in
vivo (2). Therapeutic angiogenesis is likely to require
the administration of factors that complement each
other. Activation of the receptor tyrosine kinase
KDR/Flk1 by vascular endothelial growth factor (VEGF)
is crucial, but molecular interactions of other factors
with VEGF and Flk1 have been studied to a limited
extent. Activation of KDR/Flt1 by PGF resulted
in intermolecular transphosphorylation of Flk1,
thereby amplifying VEGF-driven angiogenesis
through KDR/Flk1. Even though VEGF and PGF both
bind KDR/Flt1, PGF uniquely stimulated the
phosphorylation of specific KDR/Flt1 tyrosine residues
and the expression of distinct downstream target genes (3).

Recommended Applications
WB, IP
Applications and Recommended Dilution Factors
WB: 1:500
IP: 1:20
Species Reactivity *
Human
*Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on human placenta lysate
using anti-KDR/VEGFR-2 RabMAb (cat. # 2296-1),
dilution 1:500.

Specificity
A recombinant protein corresponding to residues in
the extracellular domain of human KDR/VEGFR2 was used as
an immunogen. It is predicted that this antibody does
not cross react with other members of the VEGF
receptor family.

Storage：
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and
0.05% BSA. Stable for 12 months from date of receipt.