Quality Standard：【产品介绍】Insulin recept o r substrates (IRS), the
maj o r intracellular substrates of the insulin recept
o r (IR), are adapt o r proteins that transduce signals
from the IR to downstream effect o r s that are imp o r
tant f o r the biological effect of insulin (1-2).
After insulin stimulation, IRS proteins are rapidly phosph
o r ylated on multiple tyrosine residues. Once phosph
o r ylated, IRS proteins bind a n d activate Grb-2, SHP2
a n d the PI3-K p85 subunit (2-3). IRS-1 functions as one
of the key regulat o r s of IR a n d the insulin-like
growth fact o r -1 recept o r . Disruption of IRS-1
causes growth retardation a n d insulin
resistance associated with
hypertension, hypertriglyceridemia, a n d
impaired endothelium-dependent vascular relaxation (4-5)
WB: 1:1,000
IHC: 1:50-100
ICC: 1:250-500
IP: 1:50
A. Western blot analysis on Hela cell lysate
using anti-IRS-1 RabMAb (cat. # 1692-1), dilution 1:1,000.
B. Immunohistochemical analysis of paraffin-embedded
human breast carcinoma using anti-IRS-1 RabMAb
(cat. # 1692-1).
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