Quality Standard：【产品介绍】Inhibin alpha chain is a peptide hormone
that inhibits the secretion of follitropin by the
pituitary gland. Inhibins and activins are involved
in regulating a number of diverse functions such
as hypothalamic and pituitary hormone secretion,
gonadal hormone secretion, germ cell development
and maturation, erythroid differentiation,
insulin secretion, nerve cell survival, embryonic
axial development or bone growth, depending on their
subunit composition (1). Granulosa-cell tumors
produce inhibin and since serum inhibin levels reflect
the size of the tumor, measurements of inhibin can be
used as a marker for primary as well as recurrent
disease (2). In the malignant regions of tissue from
men with high grade prostate cancer, the expression of
the inhibin alpha-subunit gene is suppressed and was
not detectable in poorly differentiated tumor cells.
These results demonstrate that in contrast to
ovarian granulosa cell tumors, inhibin alpha chain is
not expressed in poorly differentiated prostate cancer (3).
Recommended Applications
WB, FC
Applications and Recommended Dilution Factors
WB: 1:1000 - 2000
FC: 1:300
Species Reactivity *
Human, Mouse, Rat
*Cross reactivity determined by western blot only.
Products Data
A. Western blot analysis on (A) Hu-Adrenal gland (B)
HeLa (C) Hu-placenta and (D) LNCaP lysates
using anti-Inhibin alpha chain RabMAb
(cat. #2623-1), dilution 1:2000.
Specificity
A synthetic peptide corresponding to residues near
the N-terminus of human Inhibin alpha chain was used as
an immunogen. 20/23 kDa bands consist of the mature
alpha chain. 50/53 kDa bands are the entire proprotein.
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